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16,000+ Women, aged 50-79, mean study period of five years
PREMPRO 2.5mgs or Placebo
Journal of the American Medical Association July 8, 2002
Results best explained on the basis of the number of occurrences for 10,000 women in one year.
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Study |
Placebo |
| Coronary Heart Disease (mostly nonfatal) |
37 |
30 |
| Stroke |
29 |
21 |
| Venous Thrombosis (including pulmonary embolism) |
34 |
16 |
| Invasive Breast Cancer |
38 |
30 |
| Colorectal Cancer |
10 |
16 |
| Hip Fracture |
10 |
15 |
| Total Deaths over lengs of study |
231 |
218 |
Important points to consider:
- Does not apply directly to women who have had a hysterectomy.
- Did not study other progesterones or estrogens.
- It did not assess quality-of-life issues.
- Main new finding is effect on cardiovascular disease.
- Decisions must be individualized – requires one-on-one discussion with physician.
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