Providence Health and Services
  Home  |  Health Plans  |  Providers  |  Programs & Services  |  Hospitals & Clinics  |  Health Info  |  Employment  |  Foundations

Site Search
myProvidence:
Login
Register
 
 

 

Publications: Andrew D. Weinberg Ph.D.
 
Chief, Laboratory of Basic Immunology
Robert W. Franz Cancer Research Center

To view related abstracts of these publications, search the PubMed database.

  1. Reeves, R, Spies, AG, Nissen, MS, Buck, CD, Weinberg, AD, Barr, PJ, Magnuson, NS, Magnuson, JA.  1986. Molecular cloning of a functional bovine interleukin 2 cDNA.  Proc. Natl. Acad. Sci. USA. 83:3228.
  2. Magnuson, NS, Spies, AG, Nissen, MS, Buck, CD, Weinberg, AD, Barr, PJ, Magnuson, JA, Reeves, R.  1987. Bovine interleukin-2: Regulatory mechanisms. Vet. Immunol. Immunopathol. 17:183-192.
  3. Weinberg, AD, Elliott, JF, Paetkau, V, Bleackley, RC, Magnuson, NS, Reeves, R, Magnuson, JA. 1988. Cloning of the cDNA for the bovine interleukin-2 receptor (bovine "Tac antigen").  Immunol. 63:603-610.
  4. Weinberg, AD, Magnuson, NS, Reeves, R, Magnuson, JA. 1988. Evidence for two discrete phases of IL-2 production in bovine lymphocytes.  J. Immunol. 141:174-1179.
  5. Swain, SL, McKenzie, DT, Weinberg, AD, Hancock, W.  1988. Characterization of Th1 and Th2 helper T cell subsets in normal mice:  Helper T cells responsible for IL4 and IL5 production are present as precursors which required priming before they develop into lymphokine secreting cells.  J. Immunol. 141: 3445-3455.
  6. Carter, JJ, Weinberg, AD, Pollard, A, Reeves, R, Magnuson, JA, Magnuson, NS.  1989. Inhibition of T-lymphocyte mitogenic responses and effects on cell functions by bovine herpes virus 1.  J. Virol. 63:1525-1530.
  7. Swain, SL, Rowe, D, Dutton, RW, McKenzie, DT, Tonkonogy, S, Hancock, W, Weinberg, AD, Voland, JR. 1989. Regulation of the B cell response by helper T cells: Role of direct interaction of Th with B cells and the nature of two helper Th subsets.  In:  UCLA Symposium on Molecular and Cellular Biology, New Series.  Klinman, N., Witte, O., and Howard, M.  (Eds.)  Alan R. Liss, New York, NY, pp. 229-255.
  8. Weinberg, AD, English, M, Swain, SL. 1990. Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells. J. Immunol.. 144:800-1807.
  9. Swain, SL, Weinberg, AD, English, M.  1990. CD4+ T cell subsets:  Lymphokine secretion of memory cells and of effector cells which develop from precursors in vitro.   J. Immunol. 144:1788-1799.
  10. Weinberg, AD, Swain, SL. 1990. IL-2 receptor (Tac antigen) protein expression is downregulated by the 5'-untranslated region of the mRNA. J. Immunol. 144:4712-4720.
  11. Swain, SL, Weinberg, AD, English, M, Huston, G.  1990. IL-4 directs the development of different subsets of helper T cells.  J. Immunol.  145:3796-3806.
  12. Swain, SL, Huston, G, Tonkonogy, S, Weinberg AD.  1991. TGF-b and IL-4 Direct Helper T Cell Precursor to Develop into Distinct CD4 Helper Cells which Differ in Lymphokine Secretion Pattern and Cell Surface Phenotype.  J.  Immunol..  147:2991-3000.
  13. Swain, SL, Bradley, LM, Croft, M, Tonkonogy, S, Atkins, G, Weinberg, AD, Duncan, DD, Kaye, J, Hedrick, SM, Dutton, RW, Huston, G. 1991. Helper T cell subsets: phenotype, function and the role of lymphokines in regulating their development.  Immunol. Rev. 123:115-144.
  14. Weinberg, AD, Whitham, R, Swain, SL, Morrison, WJ, Wyrick, G, Hoy, C, Vandenbark, AA, Offner, H.  1992. TGF-b enhances the in vivo effector function and memory phenotype of antigen specific T helper cells in experimental autoimmune encephalomyelitis. J. Immunol.  148:2109-2117.
  15. Whitham, RH, Kotzin, BL, Buenafe, AC, Weinberg, AD, Jones, RE, Hashim, GA, Hoy, CM, Vandenbark, AA, Offner, H. 1993. Treatment of relapsing autoimmune encephalomyelitis with T cell receptor peptides.  J. Neuroscience Res.  35:115-128.
  16. Weinberg, AD, Wyrick, G, Celnik, B, Vainiene, M, Bakke, A, Offner, H, Vandenbark, AA. 1993. Lymphokine mRNA expression in the spinal cords of Lewis rats with EAE is associated with a host recruited CD45R hi/CD4+ population during recovery.  J. Neuroimmunol.  48:105-118.
  17. Offner, H, Buenafe, AC, Vainiene, M, Celnik, B, Weinberg, AD, Gold, DP, Hashim, G, Vandenbark, AA. 1993. Where, when, and how to detect biased expression of disease-relevant Vb genes in rats with EAE.  J. Immunol. 151:506-518.
  18. Weinberg, A.D., Celnik, B., Vainiene, M., Buenafe, A.C., Vandenbark, A.A., Offner, H.  1994. The effect of TCR Vb8 peptide protection and therapy on T cell populations isolated from the spinal cords of Lewis rats with experimental autoimmune encephalomyelitis.  J Neuroimmunol. 49:161-170.
  19. Weinberg, AD, Wallin, JJ, Jones, RE, Sullivan, TJ, Bourdette, DN, Vandenbark, AA, Offner, H. 1994.  Target organ specific upregulation of the MRC OX-40 marker and selective production of Th1 lymphokine mRNA by encephalitogenic T helper cells isolated from the spinal cord of rats with EAE.  J. Immunol. 152:4712-4721.
  20. Jones, RE, Weinberg, AD, Bourdette, D. Evidence for genetic contamination of inbred buffalo rats (RT-1b) obtained from a commercial vendor. J. Neuroimmunol. 1994. 52(2): p. 215-8.
  21. Chou, YK, Morrison, WJ, Weinberg, AD, Dedrick, R, Whitham, R, Bourdette, DN, Hashim, G, Offner, H, Vandenbark, AA.  1994.  Immunity to T cell receptor peptides in multiple sclerosis:  T cell recognition of Vb5.2 and Vb6.1 CDR2 peptides.  J. Immunol.  152:2520-2529.
  22. Chou, YK, Weinberg, AD, Buenafe, A, Bourdette, DN, Whitham, R, Kaleeba, JA, Robey, IF, Kavanagh, DG, Offner, H, Vandenbark, AA, 1996. MHC-restriction, cytokine profile, and immunoregulatory effects of human T cells specific for TCR V beta CDR2 peptides: comparison with myelin basic protein-specific T cells. J. Neurosci. Res. 45(6): p. 838-51.
  23. Weinberg, A D, Bourdette, DN, Sullivan, TJ, Lemon, M, Wallin, JJ, Maziarz, R, Davey, M, Palida, F, Godfrey, W, Engleman, E, Fulton, RJ, Offner, H, Vandenbark, AA. 1996. Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis. Nat. Med. 2:183
  24. Weinberg, AD, Lemon, M, Jones, AJ, Vainiene, M, Celnik, B, Buenafe, AC, Culbertson, N, Bakke, A, Vandenbark, AA, Offner, H. 1996. OX-40 antibody enhances for autoantigen specific V beta 8.2+ T cells within the spinal cord of Lewis rats with autoimmune encephalomyelitis. J. Neurosci. Res. 43:42.
  25. Tittle, TV, Weinberg, AD, Steinkeler, CN, Maziarz, RT. 1997. Expression of the T-cell activation antigen, OX-40, identifies alloreactive T cells in acute graft-versus-host disease. Blood. 89:4652.
  26. Vetto, JT, Lum, S, Morris, A, Sicotte, M, Davis, J, Lemon, M, Weinberg, AD. 1997. Presence of the T-cell activation marker OX-40 on tumor infiltrating lymphocytes and draining lymph node cells from patients with melanoma and head and neck cancers. Am. J. Surg. 174:258.
  27. Gramaglia, I, Weinberg, AD, Lemon, M, Croft, M. 1998. OX-40 ligand: a potent costimulatory molecule for sustaining primary CD4 T cell responses. J. Immunol.161:6510.
  28. Kaleeba, JA, Offner, H, Vandenbark, AA, Lublinski, A, Weinberg, AD. 1998. The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells. Int. Immunol. 10:453.
  29. Weinberg, AD, Vella, AT, Croft, M. 1998. OX-40: life beyond the effector T cell stage. Semin. Immunol. 10:471.
  30. Weinberg, AD. 1998. Antibodies to OX-40 (CD134) can identify and eliminate autoreactive T cells: implications for human autoimmune disease. Mol. Med. Today 4:76.
  31. Chu, Y, Hu, H-M, Winter, H, Wood, WJ, Doran, T, Lashley, D, Bashey, J, Schuster, J, Wood, J, Lowe, BA, Vetto, JT, Weinberg, AD, Puri, R, Smith, JW, Urba, WJ, Fox, BA. 1999. Examining the immune response in sentinel lymph nodes of mice and men. Eur. J. Nucl. Med. 26:S50.
  32. Weinberg, AD, Wegmann, KW, Funatake, C, Whitham, RH. 1999. Blocking OX-40/OX-40 ligand interaction in vitro and in vivo leads to decreased T cell function and amelioration of experimental allergic encephalomyelitis. J. Immunol. 162:1818.
  33. Gramaglia, I, Jember, A, Pippig, SD, Weinberg, AD, Killeen, N, Croft, M. 2000. The OX40 costimulatory receptor determines the development of CD4 memory by regulating primary clonal expansion. J. Immunol. 165:3043.
  34. Kjaergaard, J, Tanaka, J, Kim, JA, Rothchild, K, Weinberg, AD, Shu, S. 2000. Therapeutic efficacy of OX-40 receptor antibody depends on tumor immunogenicity and anatomic site of tumor growth. Cancer Res. 60:5514.
  35. Maxwell, JR, Weinberg, AD, Prell, RA, Vella, AT. 2000. Danger and OX40 receptor signaling synergize to enhance memory T cell survival by inhibiting peripheral deletion. J. Immunol. 164:107.
  36. Ramstad, T, Lawnicki, L, Vetto, J, Weinberg AD.  2000. Immunohistochemical analysis of primary breast tumors and tumor-draining lymph nodes by means of the T-cell costimulatory molecule OX-40. Am. J. Surg. 179:400.
  37. Weinberg, AD., Rivera, MM, Prell, R, Morris, A, Ramstad T, Vetto, JT, Urba, WJ, Alvord, G, Bunce, C, Shields, J. 2000. Engagement of the OX-40 receptor in vivo enhances antitumor immunity. J. Immunol. 164:2160.
  38. Evans, DE, Prell, RA, Thalhofer, CJ, Hurwitz, AA, Weinberg, AD. 2001. Engagement of OX40 enhances antigen-specific CD4 (+) T cell mobilization/memory development and humoral immunity: comparison of alphaOX-40 with alpha CTLA-4. J. Immunol. 167:6804.
  39. Kjaergaard, J, Peng, L, Cohen, PA, Drazba, JA, Weinberg, AD.  S. Shu. 2001. Augmentation versus inhibition: effects of conjunctional OX-40 receptor monoclonal antibody and IL-2 treatment on adoptive immunotherapy of advanced tumor. J. Immunol. 167:6669.
  40. Meijer, SL, Dols, A, Hu, H-M, Jensen, S, Poehlein, CH, Chu, Y, Winter, H, Yamada, J, Moudgil, T, Wood, WJ, Doran, T, Justice, L, Fisher, B, Wisner, P, Wood, J, Vetto, JT, Mehrotra, R, Rosenheim, S, Weinberg, AD, Bright, R, Walker, E, Puri, R, Smith, 2nd, JW, Urba, WJ, Fox, BA. 2001. Immunological and molecular analysis of the sentinel lymph node: a potential approach to predict outcome, tailor therapy, and optimize parameters for tumor vaccine development. J. Clin. Pharmacol. Suppl:81S.
  41. Morris, A, Vetto, JT, Ramstad, T, Funatake, CJ, Choolun, E, Entwisle, C, Weinberg, AD. 2001. Induction of anti-mammary cancer immunity by engaging the OX-40 receptor in vivo. Breast Cancer Res. Treat. 67:71.
  42. Weatherill, AR, Maxwell, JR, Takahashi, C, Weinberg, AD, Vella, AT.  2001. OX40 ligation enhances cell cycle turnover of Ag-activated CD4 T cells in vivo. Cell Immunol. 209:63.
  43. Weinberg, AD. 2001. OX-40 (CD134). Encyclopedia of Molecular Medicine. Vol. 4: 2345-2347.
  44. Petty, JK, He, K., Corless, CL, Vetto, JT, Weinberg, AD. 2002. Survival in human colorectal cancer correlates with expression of the T-cell costimulatory molecule OX-40 (CD134). Am. J. Surg. 183:512.
  45. Weinberg, AD. 2002. OX40: targeted immunotherapy--implications for tempering autoimmunity and enhancing vaccines. Trends Immunol. 23:102.
  46. Evans, DE, Weinberg, AD. 2003. Boosting T-cell costimulation in cancer: the possibilities seem endless. International Rev. Immunol. 22:173.
  47. Prell, RA, Evans, DE, Thalhofer, C, Shi, T, Fuantake, C, Weinberg, AD. 2003. OX40-mediated memory T cell generation is TNF Receptor-Associated Factor 2 Dependent. J. Immunol. 171: 5997-6005.
  48. Weinberg, AD, Evans, DE, Hurwitz, AA. 2004. Accentuating Tumor Immunity Through Costimulation. Cancer Immunotherapy at the Crossroads, How Tumors Evade Immunity and What Can Be Done. J. H. Finke, Bukowski, Ronald M.: Humana Publishing. 173-194.
  49. Streeter, PR., Zhang, X, Tittle, TV, Schon, CN, Weinberg, AD, Maziarz, RT. 2004. CD25 expression distinguishes functionally distinct alloreactive CD4 CD134 (OX40) T-cell subsets in acute graft-versus-host disease. Biol. Blood Marrow Transplant: 5 10: 298-309.
  50. Lathrop, SK, Huddleston, CA, Dullforce, PA, Montfort, MJ, Weinberg, AD, Parker, DC. 2004. A signal through OX40 (CD134) allows anergic, coreactive T cells to acquire effector cell functions. J. Immunol. 11 172: 6735-43.
  51. Sugamura, K, Ishii, N, Weinberg, AD. 2004. Targeting the Effector T Cell Costimulatory   Molecule OX40 for Therapeutic Disease Intervention. Nat. Rev, Immunol. 4: 420.
  52. Weinberg, AD, Evans, DE, Thalhofer, C, Shi, T, Prell, R. 2004. The generation of T cell memory: a review describing the molecular and cellular events following OX40 (CD134) engagement. J. Leukoc. Biol. 75: 161:962.
  53. Munks, MW, Mourich, DV, Mittler, RS, Weinberg, AD, Hill, AB. 2004. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine. Immunol. 4 112: 559-66.
  54. Valzasina, B, Guiducci, C, Dislich, H, Killeen, N, Weinberg, AD, Colombo, MP: Triggering of OX40 (CD134) on CD4+CD25+ T cells blocks their inhibitory activity: a novel regulatory role for OX40 and its comparison with GITR. Blood. 2005.
  55. Chou, YK, Edwards, DM, Weinberg, AD, Vandenbark, AA, Kotzin, BL, Fontenot, AP, Burrows, GG. 2005. Activation Pathways Implicate Anti-HLA-DP and Anti-LFA-1 Antibodies as Lead Candidates for Intervention in Chronic Berylliosis. J. Imm.  Vol 174:7 4316-4332.
  56. Weinberg, AD, Montler, R. 2005. Modulation of TNF receptor family members to inhibit autoimmune disease. Curr Drug Targets Inflamm Allergy: 2-4:195-203.
  57. Huddleston, CA, Weinberg, AD, Parker, DC. 2006. OX40 (CD134) engagement drives differentiation of CD4(+) T cells to effector cells. Eur J. Immunol Vol 36:5: 1093-103.
  58. Ruby, CE, Weinberg, AD. 2006. Regulation of CD4 T cell activation: Interplay between TNF receptor family members and the innate arm of immunity. Towards an Understanding of Initiation T Cell Immunity, ed. Vella AT, Research Signpost. 123-145.
  59. Maxwell, JR, Yadav R, Rossi, RJ, Ruby, CE, Weinberg AD, Aguila, HL, Vella, AT. 2006. IL-18 Bridges Innate and Adaptive Immunity through IFN-γ and the CD134 Pathway. J.Immunology. Vol.177: 234-245.
  60. Weinberg, AD, Thalhofer, C, Morris, N, Walker, JM, Seiss, D, Wong S, Axthelm, MK, Picker, LJ, Urba, WJ. 2006. Anti-OX40 (CD134) administration to non-human primates: immunostimulatory effects and toxicokinetic study. J. Immunother; Vol.129(6):577-585.
  61. Lepisto, AJ, Xu, M, Yagita, H, Weinberg, AD, Hendricks, RL. 2006.Expression and function of the OX40/OX40L costimulatory pair during herpes stromal keratitis. J Leukoc Biol. Dec. 21. In Press.
  62. Ruby C, Redmond, WL, Haley, D, Weinberg, AD. 2007. Anti-Ox40 stimulation in vivo enhances CD8+ memory T-cell survival and significantly increases recall responses. E J Immunol.37(1):157-166.
  63. Morris, NP, Peters, C, Montler, R, Hu, HM, Curti, BD, Urba, WJ, Weinberg, AD. 2007. Development and characterization of recombinant human Fc:OX40L fusion protein linked via a coiled coil trimerization domain. Molecular Immunology.
  64. Redmond, WL and Weinberg, AD. 2007. Targeting OX40 and OX40L for the treatment of autoimmunity and cancer. Critical Reviews in Immunology, In Press.
  65. Shu S, Kuriyama H, Watanabe S, Kjaergaard J, Tamai H, Zheng R, Weinberg AD, Hu HM, Cohen PA, Plautz GE. 2007. Mechanism of Third Signals Provided by IL-12 and OX-40R Ligation in Eliciting Therapeutic Immunity Following Dendritic-Tumor Fusion Vaccination Corresponding. Cellular Immunol. 243(1):30-40.
Home | myProvidence
Notice of Privacy Practices
Site Map | Contact | FAQ


Terms of Use and Privacy Policy | Disclaimer