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Cancer Research Laboratories
 
Chief, Laboratory of Tumor Immunology and Therapeutics
Robert W. Franz Cancer Research Center

To view related abstracts of these publications, search the PubMed database.

  1. Baca, O.G., Akporiaye, E.T., Aragon, A.S., Martinez, I.L., Robles, M.V., and Warner, N.L. Fate of Phase I and Phase II Coxiella burnetii in Several Macrophage-Like Tumor Cell Lines. Infect. Immun. 33: 258-266 (1981)
  2. Akporiaye, E.T. and Baca, O.G. Superoxide Anion Production, Superoxide Dismutase and Catalase Activities in Coxiella burnetii, J. Bacteriol. 154: 520-523 (1983)
  3. Akporiaye, E.T., Rowatt, J.D., Aragon, A.S., and Baca, O.G. Lysosomal Response of a Murine Macrophage-Like Cell Line Persistently Infected with Coxiella burnetii, Infect. Immun. 40: 1155-1162 (1983)
  4. Baca, O.G., Akporiaye, E.T., and Rowatt, J.D. Possible Biochemical Adaptations of Coxiella burnetii for Survival within Phagocytes and the Effect of Antibody, Microbiology 1984, 269-272 (1984)
  5. Akporiaye, E.T., Stewart, S.J., and Stewart, C.C. Cultivation of Murine Bone Marrow Macrophages in Sponges: A Method That Permits Complete Recovery of Viable Cultured Cells, J. Immunol. Methods 52: 149-158 (1984)
  6. Baca, O.G., Scott, O.T., Akporiaye, E.T., DeBlassie, R., and Crissman, H.A. Cell Cycle Distribution Patterns and Generation Times of L929 Fibroblast Cells Persistently Infected with Coxiella burnetii, Infect. Immun. 47: 366-369 (1985)
  7. Walker, E.B., Akporiaye, E.T., Warner, N.L., and Stewart, C.C. Characterization of Subsets of Bone Marrow-Derived Macrophages by Flow Cytometry Analysis, J. Leukocyte Biol. 37: 121-136 (1985)
  8. Akporiaye, E.T., Stewart, S.J., Stevenson, A.P., and Stewart, C.C. A Sponge Model for Studying Tumor Growth: Flow Cytometric Analysis and Quantitation of Leukocytes and Tumor Cells in the EMT6 Mouse Tumor. Cancer Res. 45, 6457-6462 (1985).
  9. Russell, S.W., Pace, J.L., Varesio, L., Akporiaye, E.T., Blasi, E., Celada, A., Schreiber, R.D., Schultz, R.M., Stevenson, A.P., Stewart, C.C. and Stewart, S.J. Comparison of Five Short-Term Assays that Measure Nonspecific Cytotoxicity Mediated to Tumor Cells by Activated Macrophages. J. Leukocyte Biol. 40: 301-313 (1986)
  10. Akporiaye, E.T., Saunders, G.C., and Kraemer, P.M. A Sponge Model for Studying Tumor Growth: Quantitation of Tumor Cells and Leukocytes in the CHO Tumor. Experientia 43: 589-593 (1987)
  11. Akporiaye, E.T., Kudalore, M., Stevenson, A.P., Kraemer, P.M. and Stewart, C.C. Isolation and Reactivity of Host Effectors Associated with the Manifestation of Concomitant Tumor Immunity. Cancer Res. 48: 1153-1158 (1988)
  12. Akporiaye, E.T. and Kudalore, M. Tumor growth inhibition by T lymphocytes recovered from a site of tumor rejection, Cancer Immunol. Immunother. 29: 199-204 (1989)
  13. Akporiaye, E.T., Tsosie, V., Stefanovich, D., and Baca, O.G. Coxiella burnetii fails to stimulate superoxide anion production by human neutrophils Acta Virol. 34: 64-70 (1990)
  14. Akporiaye, E.T. and Barbieri, C.A., Stewart, C.C., and Bender, J.G. Gelatin Sponge model of effector recruitment: Tumoricidal activity of adherent and non-adherent Lymphokine activated killer cells after culture in Interleukin-2. J. Leukocyte Biol. 49: 189-196 (1991)
  15. Heitkemper, A.L. and Akporiaye, E.T. Chemotactic activity resides primarily in the adherent population of lymphokine activated killer cells. J. Chemotherapy 3 suppl 4: 530-532 (1991)
  16. Steed, L.L., Akporiaye, E.T., and Friedman, R.L. Bordetella pertussis induces respiratory burst activity in human polymorphonuclear leukocytes. Infect. Immun. 60: 2101-2105 (1992)
  17. Friedman, R.L., Nordensson, K.., Wilson, L., Akporiaye, E.T., and Yocum, D.E. Uptake and intracellular survival of Bordetella pertussis in human macrophages. Infect. Immun. 60: 4578-4585 (1992)
  18. Akporiaye, E.T., Peterson, A., Pierce, P., Valenzuela, J., Canfield, L., and Bender, J. Effect of Beta-Carotene on cytotoxic activity and Receptor expression of tumor-specific lymphocytes. Ann. N.Y. Acad Sci. 691: 264-266 (1993)
  19. Hersh, E.M., Akporiaye, E.T., Harris, D., Stopeck, A.T., Unger, E.C., and Warnake, J.E. Clinical Protocol: Phase I study of immunotherapy of malignant melanoma by direct gene therapy. A Vical Inc. Study. Human Gene Ther. 5: 1371-1384 (1994)
  20. Kurt, R.A. Park, J.A., Panelli, M.C., Schluter, S.F., Marchalonis, J.J., and Akporiaye, E.T. T lymphocytes infiltrating sites of tumor rejection and progression display identical Vβ usage but different cytotoxic activities. J. Immunol. 154: 3969-3974 (1995)
  21. Park, J.A., Kurt, R.A., Brown, R.A., and Akporiaye, E.T. Studies of in vivo recruitment and activation of cytotoxic lymphocytes using a gelatin sponge model of concomitant tumor immunity. Int. J. Cancer. 62: 421-427 (1995)
  22. Tsang, T.C., Harris, D.T., Akporiaye, E.T., Schluter, S.F., Bowden, G.T., and Hersh, E.M. A simple method for simultaneously adapting DNA fragments and PCR products for all of the commonly used restriction sites. Biotechniques 20: 51-52 (1996)
  23. Panelli, M.C., Wang, E., Shen, S., Schluter, S.F., Bernstein, R., Hersh, E.M., Stopeck, A, Gangavalli, E.M., Barber, R., Barber, J., Jolly, D., and Akporiaye, E.T. Interferon-γ gene transfer of an EMT6 tumor that is poorly responsive to 1FN-γ stimulation: increase in tumorimmunogenicity is accompanied by induction of a mouse class II transactivator and class II MHC. Cancer Immunol. Immunother. 42: 99-107 (1996)
  24. Tsang, T.C., Harris, D.T., Akporiaye, E.T., Chu, R.S., Brailey, J., Lui, F., Vasanwala, F., Schluter, S.F., and Hersh, E.M. Mammalian expression vector with two multiple cloning sites for expression of two foreign genes. Biotechniques. 22: 68 (1997)
  25. Park, J.A., Wang, E., Kurt, R.A., Schluter, S.F., Hersh, E.M., and Akporiaye, E.T. Expression of an antisense TGF-β transgene reduces tumorigenicity of EMT6 mammary tumor cells. Cancer Gene Ther. 4: 42-50 (1997)
  26. Stopeck, A., Hersh, .M., Akporiaye, E.T., Harris, D.T., Grogan, T., Unger, E., Warneke, J., and Stahl, S. Phase I study of direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7, in patients with metastatic melanoma. J. Clin. Oncol. 15: 341-349 (1997)
  27. Rubin, J., Galanis, E., Pitot, H.C., Richardson, R.L., Burch, P.A., Charboneau, J.M., Reading, C.C., Lewis, B.D., Stahl, S., Akporiaye, E.T., and Harris, D.T. Phase I study of immunotherapy of hepatic metastases of colorectal carcinoma by direct gene transfer of an allogeneic histocompatibility antigen, HLA-B7. Gene Ther. 4: 419-425 (1997)
  28. Waddill, W., Wright, W.Jr., Unger, E., Stopeck, A., Akporiaye, E., Harris, D.T., Grogan, T., Schluter, S., Hersh, E., and Stahl, S. Human gene therapy treatment of melanoma-CT guided interstitial injection. Am. J. Roentgenol. 169: 63-67 (1997)
  29. Akporiaye, E. and Park, J.A. Elimination of tumor-mediated immunosuppression as a strategy of cancer gene therapy. Gene Ther. and Molecular Biology: From Basic Mechanisms to Clinical Applications. 2: 405-409 (1998)
  30. McEarchern J.A., Besselsen, W.G., and Akporiaye, E.T. Interferon-y and antisense TGF-β transgenes synergize to enhance the immunogenicity of a murine mammary carcinoma. Cancer Immunol. Immunother. 48: 63-70 (1999)
  31. Sharma, N., Luo, J., Kirschmann, D.A., O’Malley, Y., Robbins, M.E.C., Akporiaye, E.T., Lubaroff, D.M., Heidger, P.M., and Hendrix, M.J.C. A Novel Immunological Model for the Study of Prostate Cancer. Cancer Res. 59: 2271-2276 (1999)
  32. Galanis, E., Hersh, E.M., Stopeck, A.T., Gonzalez, R., Burch, P., Spier, C., Akporiaye, E.T., Rinehart, J.J., Edmonson, J., Sobol, R.E., Forscher, C., Sondak, V.K., Lewis, B.D., Unger, E.L., O’Driscoll, M.O., Selk, L., Rubin, J. Immunotherapy of advanced malignancy by direct gene transfer of the IL-2 DNA/DMRIE/Dope lipid complex: Phase I/II experience. J. Clin. Oncol. 17: 3313-3323 (1999)
  33. Tsang, T.C., Brailey, J.L., Vasanwala, F.H., Wu, R.S., Liu, F., Clark, P.R., Meade-Tollin, L, Luznick, L., Stopeck, A.T., Akporiaye, E.T., and Harris, D.T. Construction of new amplifier expression vectors for high levels of IL-2 gene expression. Int. J. Mol. Med. 5: 295-300 (2000)
  34. Kurt, R.A., Park, J.A., Schluter, S.F., Marchalonis, J.J., and Akporiaye, E.T. TCRVβ Usage and clonality of T cells Isolated from progressing and rejected tumor sites before and after in vitro culture. International Immunol. 12: 639-646 (2000)
  35. Graner, M, Raymond, A., Akporiaye, E. and Katsanis, E. Tumor-Derived Multiple Chaperone Enrichment by Free Solution-Isoelectric Focusing Yields Potent Anti-Tumor Vaccines. Cancer Immunol. Immunother. 49: 476-484 (2000)
  36. McEarchern, J.A., Kobie, J.J., Mack, V., Wu, RS., Meade-Tollin, L., Arteaga, C.L., Dumont, N., Besselsen, D., Seftor, E., Hendrix, M.J.C., Katsanis, E., and Akporiaye, E.T. Invasion and metastasis of a mammary tumor involves TGF-β signaling. Int. J. Cancer. 91: 76-82 (2001)
  37. Wu, R.S., Kobie, J.J., Besselsen D.G., Font, T.C., Mack, V.D., McEarchern, J.A., and Akporiaye, E.T. Comparative analysis of IFN-γ, B7.1 and antisense TGF-β gene transfer on the tumorigenicity of a poorly immunogenic metastatic mammary carcinoma. Cancer Immunol. Immunother. 50: 229-240 (2001)
  38. Robey, I.F., Schluter S.F., Akporiaye, E., Yocum D, and Marchalonis J.J. Human monoclonal autoantibodies against the T-cell receptor inhibit interleukin-2 production in murine T cells. Immunol. 105: 419-429 (2002)
  39. Kobie, J.J., Wu, R.S., Kurt, R.A., Lou, S., Adelman, M.K., Whitesell, L.J., Ramanathapuram, L.V., Arteaga, C.L., and Akporiaye, E.T., Transforming growth factor beta inhibits the antigen-presenting functions and antitumor activity of dendritic cell vaccines. Cancer Res. 63: 1860-1864 (2003)
  40. Galanis, E., Burch, P.A., Richardson, R.L., Lewis, B., Pitot, H.C., Frytak, S., Spier, C., Akporiaye, E.T., Peethambaram, P.P., Kaur, J.S., Okuno, S.H., Unni, K. K. and Rubin, J. Intratumoral Administration of a 1,2-Dimyristyloxypropyl-3-dimethylhydroxyethyl Ammo¬nium Bromide/Dioleoylphosphatidylethanolamine Formulation of the Human Interleukin-2 Gene in the Treatment of Metastatic Renal Cell Carcinoma. Cancer. 101: 2557-2565 (2004)
  41. Trevor, K.T., Cover, C., Ruiz, Y.W., Akporiaye, E.T., Hersh, E.M., Landais, D., Taylor, R.R., King, A.D. and Walters, R.E.. Generation of dendritic cell-tumor cell hybrids by electrofusion for clinical vaccine application. Cancer Immunol. Immunother. 53: 705-714
  42. Ramanathapuram LV, Kobie JJ, Bearss D, Payne CM, Trevor KT and Akporiaye ET. Alpha-tocopheryl succinate sensitizes established tumors to vaccination with non-matured dendritic cells. Cancer Immunol. Immunother. 53: 580-588 (2004)
  43. Graner MW, Likhacheva A, Davis J, Raymond A, Branderberger J, Akporiaye E and Katsanis E. Cargo from tumor-expressed albumin inhibits T cell activation and responses. Cancer Res. 64: 8085-8092 (2004)
  44. Ramanathapuram LV, Hahn T, Graner MW, Katsanis E, Akporiaye ET. Vesiculated alpha-tocopheryl succinate enhances the anti-tumor effect of dendritic cell vaccines. Cancer Immunol. Immunother. Feb:55(2):166-77, 2006 [Epub 2005 July 23].
  45. Hahn T, Alvarez I, Kobie, JJ, Ramanathapuram L, Dial S, Fulton A, Besselsen D, Walker E, Akporiaye ET. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int. J. Cancer 118: 2220-2231, 2006 [Epub 2005 Dec 05]
  46. Ramanathapuram L, Hahn T, Dial S and Akporiaye ET. Chemo-immunotherapy of breast cancer using vesiculated alpha-tocopheryl succinate in combination with dendritic cell vaccination. Nutr. Cancer 53: 177-193 (2005)
  47. Hahn T., Szabo L., Gold M., Ramanathapuram L., Hurely LH., and Akporiaye ET. Dietary administration of the pro-apoptotic vitamin E analog alpha-tocopheryloxyacetic acid inhibits metastatic murine breast cancer. Cancer Res. 66: 9374-9378, 2006.
  48. Mukherjee, P, Pathangey, L.B, Bradley, J.B, Tinder, T.L, Basu, G.B, Akporiaye, E.T, and Gendler, S.J. (2006). MUC1-specific immune therapy generates a strong anti-tumor response in a MUC1-tolerant colon cancer model. Vaccine Feb 19:25(9):1607-18 2007 [Epub 2006 Nov 16].
  49. Akporiaye ET, Bradley-Dunlop D, Gendler SJ, Mukherjee P, Madsen CS, Hahn T, Besselsen DG, Dial SM, Cui H, Trevor K. Characterization of the MUC1.Tg/MIN transgenic mouse as a model for studying antigen-specific immunotherapy of adenomas, Vaccine 2007, 25 (39-40), 6965-74
  50. Rausch MP, Hahn T, Ramanathapuram LV, Bradley-Dunlop DJ, Mahadevan D, Mercado-Pimentel ME, Runyan, RB, Besselsen, DG, Zhang X, Cheung H, Lee W, Ling L and Akporiaye ET. An orally Active Small Molecule TGF-? Receptor I Antagonist Inhibits the Growth of Metastatic Murine Breast Cancer. Anticancer Res. 2009 Jun;29(6):2099-109.
  51. Hahn T, Fried K, Hurley LH and Akporiaye ET. Orally Active alpha-TEA Suppresses Tumor Growth and Multiplicity of Spontaneous Murine Breast Cancer, Mol Cancer Ther. 2009 Jun;8(6):1570-8. Epub 2009 Jun 9

Invited Reviews

  1. Akporiaye, E.T. and Hersh, E.M. Cancer Vaccines: Clinical Applications: Immune Adjuvants: In: Biologic Therapy of Cancer. Devita, V.T., S. Hellman and S.A. Rosenberg (eds) J.B. Lippincott Co. Philadelphia. pgs. 635-647, 1995.
  2. Akporiaye, E. and Park, J.A. Elimination of tumor-mediated immunosuppression as a strategy of cancer gene therapy. Gene Ther. and Molecular Biology: From Basic Mechanisms to Clinical Applications. 2:405-409, 1998.
  3. Akporiaye, E.T. and Hersh, E. Clinical aspects of intratumoral gene therapy. Curr. Opinion Mol. Ther.1a;443-453, 1999.
  4. Lake, D., Akporiaye, E.T., and Hersh, E.M. Immunopharmacology (8th Edition) In: Basic and Clinical Pharmacology, B.G. Katzung (ed.) McGraw Hill, NY. pgs. 959-986, 2001.
  5. Kobie J.J. and Akporiaye, E.T. Immunosuppressive role of transforming growth factor-beta in breast cancer. Clinical and Applied Immunology Reviews 3: 277-287, 2003.
  6. Hahn T, Akporiaye ET. Targeting transforming growth factor beta to enhance cancer immunotherapy. Curr Oncology 2006; 13(4):141-43
  7. Neuzil, J, Dong L-F, Ramanathapuram L, Hahn T, Chladova M, Xiu-Fang Wang X-F, Zobalova R, Prochazka L, Gold M, Freeman R, Turanek J, Akporiaye ET, Dyason JC and Ralph SJ. Vitamin E analogues as a novel group of mitocans: Anti-cancer agents that act by targeting mitochondria. Molecular Aspects of Medicine 28 (2007) 607-645
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