Publications: Edwin B. Walker, Ph.D.

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1. Warner, NL, Burcheil, SW, Walker, EB, Richey, JB, Leary, J, McGlaughlin, S. Characterization of murine B cell lymphomas and macrophage tumors by flow microfluorometry and Functional assays. In: Immunobiology and Immunotherapy of Cancer, Elsevier, North Holland. 1979.
2. Walker, EB, Van Epps, DE, Warner, NL. Macrophage Chemiluminescence. In: Manual of Macrophage Methodology, Marcel Dekkar, Inc., New York. 1981.
3. Warner, NL, Cheney, R, Daley, M, Lanier, L, Walker, EB.  Intratumor differentiation heterogeneity in murine hematopoietic tumors.  In: Maturation Factors in Cancer. Raven Press, New York. 1981.
4. McKean, DJ, Infante, AK, Nilson, A, Kimoto, M, Fathman, DG, Walker, EB, Warner, NL.  Major histocompatibility complex-restricted antigen presentation to antigen-reactive T cells by B lymphocyte tumor cells.  J Experimental Med. 154:1419. 1981.
5. Warner, NL, Lanier, LL, Walker, EB, Stewart, CC, Wood, G, Balch, C. Hematopoietic tumors: normal or abnormal models of leukocyte differentiation.  In: Hybridomas and Cellular Immortality. Plenum Press, New York. 1982.
6. Lanier, LL, Walker, EB, Richie, R-R, Warner, NL. Murine hematopoietic cell tumors: models for analysis of cellular differentiation.  In: B and T Cell Tumors - Biological and Clinical Aspects.  UCLA Symposium on Molecular and Cellular Biology. Academic Press, New York. 1982.
7. Wharton, W, Walker, EB, Stewart, C. Growth regulation by macrophage. In: Proceedings of the Ninth Reticuloendothelial Society Conference. Plenum Press, New York, 1982.
8. Walker, EB, Lanier, L, Warner, NL. Concomitant induction of the cell surface expression of Ia determinants and accessory cell function by a murine macrophage tumor cell line. J Experimental Medicine. 155:629. 1982.
9. Walker, EB, Lanier, L, Warner, NL. Characterization and functional properties of tumor cell lines in accessory cell replacement assays.  J Immuno. 128:852. 1982.
10. Walker, EB, Warner, NL, Chesnut, R, Kappler, J, Marrack, P. Antigen specific, I region-restricted interactions in vitro between tumor cell lines and T-cell hybridomas.  J Immuno. 128:2164. 1982.
11. Stewart, CC, Walker, EB, Warner, NL, Walker, W.  Mononuclear phagocyte proliferation and differentiation.  Mononuclear Phagocyte Biology. Marcel Dekker, Inc., New York. 1984.
12. Stewart, CC, Walker, EB, Warner, NL, Walker, W. Clonal analysis of bone marrow macrophage cultures.  In: Proceedings of the Fourth Leiden Conference on Mononuclear Phagocytes. Martinues Nighoff, Netherlands. 1984.
13. Walker, EB, Maino, VB, Sanchez-Lanier, M, Warner, N, Stewart, C. Murine interferon activates the release of a macrophage-derived, Ia-inducing factor which transfers Ia inductive capacity.  J Experimental Medicine. 159:1532-1537. 1984.
14. Walker, EB, Akporiaye, ET, Warner, NL, Stewart, CC. Characterization of subsets of bone marrow defived macrophage by flow cytometry analysis.  J Leukocyte Biology. 37:121-136. 1985.
15. Kelly, LW, Brief, S, Westley, HJ, Novakafski, J, Bechtel, PJ, Simon, J, Walker, EB. GH3 pituitary adenoma cells can reverse thymic aging in rats.  Proceedings of the National Academy of Science. 83:5663-5667. 1986.
16. Walker, EB, and Leemhuis, T. The same cloned murine B Lymphoma cell lines can be selectively induced to release either Interleukin-1 or Interleukin-2 like factor activity.  J Lymphokine Research. 6:71-81. 1987.
17. Kelley, KW, Brief, S, Westley, HJ, Novakafski, H, Bechtel, PJ, Simon, J, Walker, EB. Hormonal regulation of the age-associated decline in immune function.  Annals of the New York Academy of Science. 496:91. 1987.
18. Boswell, HS, Burgess, JS, Srivastava, A, Podgett, G, Walker, EB, Geib, RW. Cellular control of in vitro progression of murine myeloid leukemia: transformation accompanies acquisition of growth factor and stromal cell independence.  Leukemia. 1:765-771. 1987.
19. Li, Lu, Walker, DE, Broxmeyer, HE, Hoffman, R, Wen Hu, Walker, EB. Characterization of adult human marrow hematopoietic progenitors highly enriched by two color cell sorting with MY 10 and major histocompatibility class II monoclonal antibodies.  J Immuno. 139:1823-1829. 1987.
20. Park, MM, and Walker, EB. Characterization of a T cell subset prevalent in immunoregulatory disorders in humans.  Cellular Immunology. 111:265-272. 1988.
21. Walker, EB, Leemhuis, T, Roeder, W. Murine B Lymphoma cell lines release functionally active IL-2 after stimulation by Staphylococcus aureus.  J Immuno. 140:859-865. 1988.
22. Downing, J, Martinez-Valdes, H, Elizondo, RS, Walker, EB, Taylor, M. Hyperthermia in humans enhances interferon-gamma synthesis and alters the peripheral lymphocyte population.  J of Interferon Research. 8:139-146. 1988.
23. Li, Lu, Srour, EF, Warren, DJ, Walker, D, Graham, DD, Walker, EB, Jansen, J, Broxmeyer, JE. Enhancement of release of granulocyte- and granulocyte-macrophage Colony-stimulating factors from phytohemagglutinin-stimulated, sorted subsets of human T lymphocytes by recombinant human tumor necrosis factor-alpha. J lmmuno. 141:201-207. 1988.
24. Brandt, J, Lu, L, Walker, E, Hoffman, R. Detection of human hematopoietic progenitor cells capable of forming blast cell containing colonies in vitro. Advances in Experimental Medicine and Biology. 241:165-173. 1988.
25. Srour, EF, Walker, EB, Walker, DE, Jansen, J. Functional and phenotypical studies of the
    leu-4 (CD3)+, leu-1 (CD5)- lymphocyte.  Clinical and Experimental Immunology. 73:34-39. 1988.
26. Geissler, K, Tricot, G, Leemhuis, T, Walker, EB, Broxmeyer, HE. Differentiation-inducing effect of recombinant human tumor necrosis factor alpha and gamma-interferon in vitro on blast cells from patients with acute myeloid leukemia and myeloid blast crisis of chronic myeloid leukemia. Cancer Research. 49:3057-3062. 1989.
27. Boswell, JS, Mochizuki, D, Burgess, GS, Gillis, S, Walker, EB, Williams, DE. A novel mast cell growth factor (MCGF-3) produced by marrow adherent cells that synergizes with interleukin-3 and interleukin-4. Experimental Hematology.  18:794. 1990.
28. Schnizlein-Bick, CT, Magier, MR, Jones, RB, Fife, KH, Katz, BP, Walker, EB. Differences among mononuclear cell populations in HIV seropositive or seronegative homosexual and heterosexual males as determined by four-color flow cytometry. J Acq Immune Deficiency Syndromes (AIDS). 3: 747-756. 1990.
29. Walker, EB. Four color flow cytometry. In: Handbook of Flow Cytometry Methods. International Society for Analytical Cytology and Purdue University Cytometry Laboratories. 1990.
30. Tsonis, PA, and Walker, EB.  Cell populations synthesizing cartilage proteoglycan core protein in the early chick limb bud. Biochemica, Biophysica Research Communications. 174:688-695. 1991.
31. Hustmyer, FG, Walker, E, Xiao-Peng, Y, Girasole, G, Sakagarni, Y, Peacock, M, Manolagas, SC. Cytokine production and surface antigen expression by peripheral blood mononuclear cells in postmenopausal osteoporosis.  Journal of Bone and Mineral Research. 8(1):51. 1993.
32. Clemo, FAS, Crabtree, W, Walker, E, DeNicola, DB. Comparison of image analysis and flow cytometric measurements of DNA content of canine transitional cell carcinomas. Analytical and Quantative Cytology and Histology. 15(6):418-426. 1993.
33. Clemo, FAS, DeNicola, DB, Carlton, WW, Morrison, WB, Walker, E. Flow cytometric DNA ploidy analysis in canine transitional cell carcinoma of urinary bladder. Veterinary Pathology. 31(2):207-215. 1994.
34. Clemo, FAS, DeNicola, DB, Carlton, WW, Walker, EB, Morrison, WB. Immunoreactivity of canine transitional cell carcinoma of the urinary bladder with monoclonal antibody to tumor associated glycoprotein 72. Veterinary Pathology. 32(2):155-161. 1995.
35. de Riese, WT, de Riese, C, Ulbright, TM, Walker, EB, Messemer, J, Jones, JA, Reister, T, Albers, P, Allhoff, EP, Foster, RS. Flow Cytometric and quantitative histologic parameters as prognostic indicators for occult retroperitoneal disease in clinical - Stage - I non-seminomatous testicular germ cell tumors. Int J Cancer. 57(5): 628-633. 1994.
36. de Riese, WT, Albers, P, Walker, EB, Ulbright, TM, Crabtree, WN, Reister, T, Foster, RS, Donohue, JP. Predictive parameters of biologic behavior of early stage non-seminomatous testicular germ cell tumors. Cancer. 74(4):1335-1341. 1994.
37. Albers, P, de Riese, WT, Walker, EB, Ulbright, TM, Crabtree, WN, Reister, T, Foster RS, Donohue, JP. Predictive parameters in biologic assessment of low-stage retroperitoneal node dissection. World J Urol. 12(3): 120-4. 1994.
38. de Riese, WT, Walker, EB, de Riese, C, Ulbright, TM, Crabtree, WN, Messemer, J, Jones, JA, Hinkel, A, Foster, RS, Donohue, JP, et al. Quantitative DNA measurement by flow cyometry and image analysis of human nonseminomatous germ cell testicular tumors. Urol Res. 22(4):213-20. 1994.
39. Zhao, L, Griggs, LN, Elliott, GT, Walker, EB. Effects of nitric oxide and monophosphoryl lipid A on leukocyte transmigration across endothelial cell monolayers. Int J Immunotherapy. XIV(2):57-67. 1997.
40. Pfau, JC, Walker, EB, Card, GL. A comparison of the effects of lipopolysaccharide and ceramide on arachidonic acid metabolism in THP-1 monocytic cells. Cellular Immunol. 186(2):147-153. 1998.
41. Phau, JC, Walker, EB, Card, GL. Monoclonal antibodies to CD45 modify LPS-induced arachidonic acid metabolism in macrophages. Biochemica et Biophysica Acta. 1492:212-220. 2000.
42. Elliott, GT, Sowell, CG, Walker, EB, Weber, PA, Moore, J, Gross, GJ. The novel glycolipid RC-552 attenuates myocardial stunning and reduces infarct size in dogs. J Mol Cell Cardio. 32(7):1327-39. 2000.
43. Meijer, SL, Dols, A, Hu, H-M, Jensen, S, Poehlein, CH, Chu, Y, Winter, H, Yamada, J, Moudgil, T, Wood, WJ, Doran, T, Justice, L, Fisher, B, Wisner, P, Mehrotra, R, Rosenheim, S, Weinberg, AD, Bright, R, Walker, EB, Puri, R, Smith II, JW, Urba, WJ, Fox, BA. Immunological and Molecular Analysis of the Sentinel Lymph Node: A Potential Approach to Predict Outcome, Tailor Therapy, and Optimize Parameters for Tumor Vaccine Development. J. Clin. Pharmacol. 41:81S-94S. 2001.
44. Walker, EB and Disis, ML. Monitoring immune responses in cancer patients receiving tumor vaccines. International Reviews of Immunology. 22:283-319. 2002.
45. Smith, JW, Walker, EB, Fox, BA, Haley, D, Wisner, KP, Doran, T, Fisher, B, Justice, L, Wood, W, Vetto, J, Maecker, H, Dols, A, Meijer, S, Hu, HM, Romero, P, Alvord, WG, Urba, WJ. Adjuvant immunization of HLA-A2-positive melanoma patients with a modified gp100 peptide induces peptide-specific CD8+ T-cell responses. J Clin Oncol. 21:1562-1573. 2003.
46. Dols, A, Meijer, SL, Smith, JW, Fox, BA, Urba, WJ. Allogeneic breast cancer cell vaccines. Clin Breast Cancer 3 Suppl 4: S173-80. February 2003.
47. Dols, A, Smith, J, Meijer, SL, Fox, BA, Hu, HM, Walker, E, Rosenheim, S, Moudgil, T, Doran, T, Wood, W, Seligman, M, Alvord, WG, Schoof, D, Urba, WJ. Vaccination of Women with Metastatic Breast Cancer, Using a Costimulatory Gene (CD80)-Modified, HLA-A2-Matched, Allogeneic, Breast Cancer Cell Line: Clinical and Immunological Results. Human Gene Therapy. 14:000-000:1-7. 2003.
48. Dols, A, Smith II, J, Meijer, SL, Fox, BA, Hu, HM, Walker, E, Rosenheim, S, Moudgil, T, Doran, T, Wood, W, Seligman, M, Alvord, WG, Schoof, D, Urba, WJ. Vaccination of Women with Metastatic Breast Cancer, Using a Costimulatory Gene (CD80)-Modified, HLA-A2-Matched, Allogeneic, Breast Cancer Cell Line: Clinical and Immunological Results. Human Gene Therapy. 14:000-000:1-7. 2003.
49. Hu, HM, Dols, A, Meijer, S, Floyd, K, Walker, E, Urba, W, Fox, B. Immunological monitoring of melanoma patients following peptide vaccination using soluble peptide/HLA-A2 dimer complexes. J Immunotherapy. 27:1. Jan/Feb 2004.
50. Walker, EB, Haley, D, Miller, W, Floyd, K, Wisner, KP, Sanjuan, N, Maecker, H, Romero, P, Hu, HM, Alvord, WG, Smith II, JW, Fox, BA, Urba, WJ. gp100209-2M Peptide Immunization of HLA-A2+ Stage I-III Melanoma Patients Induces Significant Increase in Antigen-Specific Effector and Long-Term Memory CD8+ T Cells. J. Clinical Cancer Res. 10:668-680 January 15, 2004.
51. Ma, JP, Poehlein, CH, Jensen, SM, LaCelle, MG, Moudgil, TM, Ruttinger, D, Haley, D., Goldstein, MJ, Smith II, JW, Curti, B, Ross, H, Walker, E, Hu, HM, Urba, WJ, Fox, BA. Manipulating the Host Response to Autologous Tumour Vaccines. Dev Biol; Development of Therapeutic Cancer Vaccines. 116:93-104. 2004.
52. Hahn, T, Alavarez, I, Kobie, JJ, Ramanathanpuram, L, Dial, S, Fulton, A, Besselsen, D, Walker, E, Akporiaye, ET. Short-term dietary administration of celecoxib enhances the efficacy of tumor lysate-pulsed dendritic cell vaccines in treating murine breast cancer. Int J Cancer. 118(9):2220-31. 2005
53. He, H, Wisner, P, Yang, G, Hu, H, Haley, D, Miller, W, O’Hara, Alvord,WG, Clegg, CH, Fox, BA, Urba, WJ, Walker, EB. Combined IL-21 and Low-Dose IL-2 therapy induces anti-tumor immunity and long-term curative effects in a murine melanoma tumor model. J Translation Medicine. 4:24. 2006
54. Petrausch, U, Haley, D, Miller, W, Floyd, K, Urba, WJ, Walker, EB.  Polychromatic flow cytometry: A rapid method for the reduction and analysis of complex multiparameter data. Cytometry Part A. 69(12):1162-1173. Dec. 2006
55. Urba, WJ, Meijer, SL, Dols, A, Jensen, SM, Hu, HM, Miller W, Walker, EB, Romero, P, Fox, BA. Induction of circulating tumor-reactive CD8+ T cells following vaccination of melanoma patients with the gp100209-2M peptide. J Immunotherapy. 2007. In Press
    

Patents:

Walker, E. B., and Sowell, G.: Methods of Modulating Dendritic Cells UsingAdjuvants. Serial number: 60/220,081; Filed: July 21, 2000.