Photo of Dennis R. Holmes, MD

Dennis R. Holmes, MD

Accepting New Patients
Offers Video Visits
1505 Wilson Terrace, Suite 370
Glendale, CA 91206
2268.9 miles away
Medical Groups & Affiliations
Saint John's Physician Partners Affiliated Providers
Speaks: English

Dennis Holmes, MD, Inc.

1505 Wilson Terrace, Suite 370, Glendale, CA 91206

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About Dennis R. Holmes

Dr. Holmes is a dedicated breast surgeon and cancer researcher who recently held the position of Director of the Margie Petersen Breast Center at St. John’s Health Center. Formerly, Dr. Holmes held the positions of Chief Breast Surgeon and Medical Director of the Los Angeles Center for Women’s Health, and Chief Breast Cancer Surgeon, and Breast Cancer Research Committee Co-Chair at the University of Southern California (U.S.C.) Kenneth Norris Comprehensive Cancer Center.

FELLOWSHIP-TRAINED. Dr. Holmes is a 2003 graduate of the U.S.C. Breast Surgery Fellowship Training Program, one of most progressive breast surgery training programs in the U.S. Years later, he ascended to the position Program Chair and in the process had the privilege of supervising the training of over 30 dedicated breast surgeons. As evidence of his commitment to education, Dr. Holmes was selected to Chair the 2019 Annual Meeting of the American Society of Breast Surgeons, an annual educational meeting of over 3,000 breast surgeons.

LEADER. Dr. Holmes currently serves in the leadership of several national surgical societies and is a frequent lecturer at conferences worldwide. Dr. Holmes is a Fellow of the American College of Surgeons; President of the TARGIT Collaborative Group (a national research and education organization in intraoperative radiotherapy); National Principal Investigator of the FROST Trial, a clinical trial evaluating the use of cryoablation (tumor freezing) instead of surgery for the treatment of early stage breast cancer; and serves and Principal or Co-investigator in several additional clinical trials.

INNOVATOR. Widely respected by colleagues for his innovative approach to breast cancer care, Dr. Holmes has distinguished himself by his pioneering work in oncoplastic surgery, intraoperative radiotherapy, cryoablation, genetic testing, neoadjuvant chemotherapy, lymph node-sparing surgery, and minimally-invasive breast surgery. However, what most distinguishes Dr. Holmes among breast surgeons is his high level of commitment to providing women with treatment options that suit their personal physical and emotional needs, while also providing the best possible cancer control.


LAC+USC Medical Center


LAC+USC Medical Center

Medical School

Tulane University


Alameda Health System Highland Hospital


Barnes-Jewish Hospital


Barnes-Jewish Hospital

Board Certifications
  • American Board of Surgery, Surgery
Dennis Holmes, MD, Inc.
1505 Wilson Terrace, Suite 370
Glendale, CA 91206

Medical Groups & Affiliations
Saint John's Physician Partners Affiliated Providers

Affiliated Locations
Providence Saint John's Health Center

Clinical Interests

  • Abdominal Cancer Surgery
  • Abnormal Mammogram
  • Acquired Absence Of Breast
  • Acquired Deformity Of Reconstructed Breast
  • Adolescent And Young Adult Cancer (Aya)
  • Adolescent Breast Disorders
  • Adrenal Neoplasm
  • Amastia
  • Amazia
  • Anal Cancer Surgery
  • Anorectal Cancer
  • Anorectal Cancer Surgery
  • Appendiceal Cancer
  • Appendiceal Cancer Surgery
  • Appendiceal Carcinoid
  • Areola Sparing Mastectomy
  • Aspiration Breast Cyst
  • Atypical Ductal Hyperplasia
  • Atypical Lobular Hyperplasia
  • Axillary Lymphadenectomy
  • Axillary Lymphadenopathy
  • Axillary Mass
  • Benign Breast Lump
  • Bile Duct Cancer Surgery
  • Biliary Tract Cancer Surgery
  • Bladder Cancer Surgery
  • Bloodless Breast Surgery
  • Bone Cancer Surgery
  • Brain Cancer Surgery
  • Breast Abscess
  • Breast Atrophy
  • Breast Augmentation
  • Breast Biopsy
  • Breast Calcification
  • Breast Cancer
  • Breast Cancer Risk Factors
  • Breast Cancer Screening
  • Breast Cancer Surgery
  • Breast Cancer Symptoms
  • Breast Conservation
  • Breast Cyst
  • Breast Deformities
  • Breast Diseases
  • Breast Examination
  • Breast Fine Needle Aspiration
  • Breast Hyperplasia
  • Breast Implant Illness
  • Breast Implant Rupture
  • Breast Lump
  • Breast Prosthesis
  • Breast Reconstruction
  • Breast Reconstruction With Flap Surgery
  • Breast Reduction
  • Breast Reinnervation
  • Breast Surgery
  • Breast Surgery Revision
  • Cancer Risk
  • Cancer Risk Reduction Surgery
  • Cancer Surgery
  • Cancerous Tumor Removal Of The Hand
  • Carcinoid Of Stomach
  • Carcinoma In Situ Of Breast
  • Central Compartment Neck Dissection
  • Cervical Cancer Cryotherapy
  • Cervical Cancer Surgery
  • Cervical Plexopathy
  • Cholangiocarcinoma
  • Colon Cancer Surgery
  • Colorectal Cancer
  • Colorectal Cancer Surgery
  • Colorectal Metastases
  • Congenital Breast Deformities
  • Congenital Hypoplasia Of Breast
  • Contusion Of Breast
  • Cryoablation
  • Cystic Pancreatic Neuroendocrine Tumors
  • Cytoreduction Surgery
  • Deformity Of Reconstructed Breast
  • Direct To Implant Reconstruction
  • Disproportion Of Reconstructed Breast
  • Ductal Carcinoma In Situ (Dcis)
  • Dysplasia Of Breast
  • Ear Canal Cancer Surgery
  • Ear Cancer Surgery
  • Early Breast Cancer Signs
  • Endometrial Cancer Surgery
  • Endoscopic Breast Augmentation
  • Er Positive Breast Cancer
  • Esophageal Cancer Surgery
  • Esophagogastrectomy
  • Excision Of Breast Lesion
  • Eye Cancer Surgery
  • Eyelid Cancer Surgery
  • Face Cancer Surgery
  • Fallopian Tube Cancer Surgery
  • Family History Of Breast Cancer
  • Fibroadenoma
  • Fibrocystic Breast Changes
  • Fibrosarcoma
  • Galactocele
  • Galactorrhea
  • Gallbladder Cancer Surgery
  • Gastrectomy
  • Gastric Lymphoma
  • Gastroesophageal Junction Cancer Surgery
  • Gastrointestinal (Gi) Cancer
  • Gastrointestinal (Gi) Cancer Surgery
  • Gastrointestinal Stromal Tumor Surgery
  • Gender Affirming Mastectomy
  • Glossectomy
  • Glottis Cancer Surgery
  • Goldilocks Mastectomy
  • Gynecologic (Gyn) Cancer
  • Gynecologic Cancer Surgery
  • Head Cancer Surgery
  • Hemangioendothelioma Of Liver
  • Hepatic Artery Infusion Pump
  • Hepatic Artery Infusion Pump Placement
  • Her2 Positive Breast Cancer
  • Hereditary Breast And Ovarian Cancer
  • Hereditary Colon Cancer
  • Hickman Catheter
  • History Of Breast Cancer
  • History Of Fibrocystic Disease
  • Hormone Receptor Positive Breast Cancer
  • Hybrid Breast Reconstruction
  • Hypertrophy Of Breast
  • Hypopharyngeal Cancer Surgery
  • Hypopigmented Nipple Lesions
  • Hypoplasia Of Breast
  • Inflammatory Breast Cancer
  • Intra Abdominal Cancer
  • Intraarterial Chemotherapy Of Tumors
  • Intraoperative Molecular Imaging
  • Juvenile Breast Hypertrophy
  • Juvenile Fibroadenoma Of The Breast
  • Kidney Cancer Surgery
  • Labia Cancer Surgery
  • Laparoscopic Whipple Procedure
  • Large Cell Neuroendocrine Tumors
  • Leiomyosarcoma
  • Liposarcoma
  • Liver Cancer
  • Liver Cancer Surgery
  • Lobular Carcinoma In Situ (Lcis)
  • Lobular Neoplasia
  • Lumbar Spine Tumor
  • Lumpectomy
  • Lumpectomy Revision
  • Lung Cancer Surgery
  • Lymph Node Dissection
  • Lymph Node Surgery Penis
  • Lymphadenopathy
  • Lymphedema
  • Male Breast Cancer
  • Male Breast Reduction
  • Malignant Carcinoid Tumor Of Colon
  • Malignant Melanoma
  • Mammary Duct Ectasia
  • Mammary Dysplasia
  • Mammogram
  • Mastectomy
  • Mastitis
  • Mastodynia
  • Mastoplasty
  • Mastotomy
  • Mediastinum Cancer Surgery
  • Melanoma
  • Melanoma Surgery
  • Metastatic Breast Cancer
  • Metastatic Colon Cancer
  • Metastatic Liver Cancer
  • Metastatic Melanoma
  • Metastatic Rib Cancer
  • Microcalcifications
  • Micromastia
  • Minimally Invasive Gastric Tumor Surgery
  • Minimally Invasive Lung Cancer Surgery
  • Minimally Invasive Lymph Node Dissection
  • Mondor's Disease
  • Mouth Cancer Surgery
  • Myometrial Cancer Surgery
  • Nasal Cavity Cancer
  • Nasal Cavity Cancer Surgery
  • Nasopharyngeal Cancer Surgery
  • Neck Cancer Surgery
  • Nerve-Sparing Retroperitoneal Lymph Node Dissection
  • Neuroendocrine Tumor Of The Appendix
  • Neuroendocrine Tumor Of The Bowel
  • Neuroendocrine Tumor Of The Colon
  • Neuroendocrine Tumor Of The Pancreas
  • Neuroendocrine Tumor Of The Stomach
  • Neuroendocrine Tumor Surgery
  • Neuroendocrine Tumors
  • Nipple Discharge
  • Nipple Diseases
  • Nipple Fissure
  • Nipple Lesions
  • Nipple Reinnervation
  • Nipple Repair
  • Nipple Sparing Mastectomy
  • Oncoplastic Breast Surgery
  • Orbit Cancer Surgery
  • Oropharyngeal Cancer Surgery
  • Outer Ear Cancer Surgery
  • Ovarian Cancer Surgery
  • Palate Cancer Surgery
  • Pancreas Cancer
  • Pancreas Cancer Surgery
  • Pancreas Head Cancer Surgery
  • Pancreas Tail Cancer Surgery
  • Pancreatectomy
  • Pancreatic Cancer Risk Assessment
  • Parathyroid Cancer Sugery
  • Parotid Cancer Surgery
  • Pelvic Mass
  • Penile Cancer Surgery
  • Peritonectomy
  • Personalized Cancer Therapy
  • Polymastia
  • Post-Chemotherapy Retroperitoneal Lymph Node Dissection
  • Postmastectomy Lymphedema Syndrome
  • Postpartum Mastitis
  • Preoperative Chemotherapy
  • Prepectoral Breast Reconstruction
  • Prostate Cancer Surgery
  • Proximal Pancreatectomy
  • Pseudopapillary Tumors
  • Ptosis Of Breasts
  • Radiation Induced Breast Deformity
  • Radiation Therapy Simulation
  • Radical Inguinal Orchiectomy
  • Radical Subtotal Pancreatectomy
  • Reconstructive Surgery Of The Nipple
  • Resensation Technique
  • Retroperitoneal Liposarcoma
  • Retroperitoneal Sarcoma
  • Retroperitoneal Sarcoma Resection
  • Rib Cancer Surgery
  • Robotic Glossectomy
  • Robotic Liver Resection
  • Robotic Surgery For Bladder Cancer
  • Robotic Surgery For Kidney Cancer
  • Ruptured Implant
  • Salvage Prostatectomy
  • Sarcoma
  • Scar Hypertrophy
  • Sentinel Lymph Node Biopsy
  • Sentinel Node Biopsy
  • Sinus Cancer Surgery
  • Skin Cancer
  • Skin Sparing Mastectomy
  • Small Bowel Cancer
  • Small Intestine Cancer Surgery
  • Spine Mets
  • Spleen Cancer Surgery
  • Squamous Cell Carcinoma
  • Staging Laparotomy
  • Stomach Cancer
  • Stomach Cancer Surgery
  • Stromal Tumor Of Intestine
  • Subpectoral Placement
  • Supernumerary Nipple
  • Supraglottic Cancer
  • Supraglottoplasty
  • Surgical Management Of Advanced Hepato Biliary Cancer
  • Surgical Management Of Advanced Pancreatic Cancer
  • Surgical Staging
  • Symmastia
  • Testicular Cancer Surgery
  • Thoracodorsal Artery Perforator Flap
  • Triple Negative Breast Cancer
  • Vocal Cord Cancer Surgery
  • Whipple Procedure
  • Wide Local Excision Surgery